NOVELTY - Prevention and curing of grape brown spot disease, involves applying fertilizer, applying HYT-A (RTM: Foliar nutrient solution produced by microbial fermentation), HYT-B (RTM: Foliar nutrient solution produced by microbial fermentation), HYT-C (RTM: Foliar nutrient solution produced by microbial fermentation), applying organic fertilizer, biologically controlling by intercropping with Pyrethrum, spraying polymyxin agent, and carrying out physical and chemical controls.    USE - The method is useful for comprehensive prevention and curing of grape brown spot disease (claimed).    ADVANTAGE - The method reduces the grape disease incidence spot, and increases the yield and quality of grape.    DETAILED DESCRIPTION - Comprehensive prevention and curing of grape brown spot disease involves carrying out ecological management, applying 200-400 ml fertilizer per acre of fruit trees, administering 200-250 ml HYT-A (RTM: Foliar nutrient solution produced by microbial fermentation), 250-300 ml HYT-B (RTM: Foliar nutrient solution produced by microbial fermentation), 100-120 ml HYT-C (RTM: Foliar nutrient solution produced by microbial fermentation) for 2-4 times throughout the growing period, applying 20-25 g/acre traditional Chinese medicine micro fertilizer in 3 months before the ripening of grape, carrying out agricultural control during the growth of grapes and orchard, timely topping, strengthening air and light, reducing humidity of orchard, administering 60-80 kg effective microorganism organic fertilizer, carrying out biological control by intercropping Pyrethrum or other non-host plants in the vineyard, blocking the spread of germs, carrying out biological control by spraying 0.3% polymyxin agent 300 times, carrying out physical control by eliminating orchard Autumn leaves and centralized burning to reduce or eliminate overwintering pathogen, and carrying out chemical control by spraying 80% Mancozeb (RTM: Fungicide) wettable powder 500 times or 58% metalaxyl manganese and zinc 500 times, and sprinkling for 3 times.