NOVELTY - Synthesis of dasatinib (I) involves obtaining N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound (IV), carrying out coupling reaction of N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound (IV) with 2-(piperazin-1-yl)ethan-1-ol (III) in a solvent (c) in the presence of a base (d), obtaining N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound (II), performing simultaneous deprotection of obtained N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound (II), and obtaining dasatinib or its salt.    USE - Synthesis of dasatinib used for treating chronic myelogenous leukemia.    ADVANTAGE - The method enables synthesis of dasatinib with excellent handleability and high yield, by simple, economical, and environmentally-friendly process.    DETAILED DESCRIPTION - Synthesis of dasatinib of formula (I) involves reacting 1-(2-amino-1,3-thiazol-5-yl)ethane-1,1-dione of formula (X) with 4,6-dichloro-2-methylpyrimidine of formula (IX) in an aprotic polar solvent (a) in the presence of a base (b), obtaining 1-(2-((6-chloro-2-methylpyrimidin-4-yl)amino)-1,3-thiazol-5-yl)ethane-1,1-dione of formula (VIII), carrying out protecting reaction of 1-(2-((6-chloro-2-methylpyrimidin-4-yl)amino)-1,3-thiazol-5-yl)ethane-1,1-dione, obtaining N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound of formula (VII), performing hydrolysis reaction of N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound (VII), obtaining N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound of formula (VI), reacting N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound (VI) with 2-chloro-6-methylaniline of formula (V), obtaining N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound of formula (IV), carrying out coupling reaction of N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound (IV) with 2-(piperazin-1-yl)ethan-1-ol of formula (III) in a solvent (c) in the presence of a base (d), obtaining N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound of formula (II), performing simultaneous deprotection of obtained N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound (II), and obtaining dasatinib or its salt.    PG'=amine protecting group.    An INDEPENDENT CLAIM is included for N-(6-chloro-2-methylpyrimidin-4-yl)-1,3-thiazol-2-amine compound of formulae (VII), (VI), (IV), (II), and (VIa).