NOVELTY - Preparation of troxipide includes adding 3,4,5-Trimethoxy-N-pyridin-3-yl-benzamide hydrochloride and water in an autoclave, and heating; adding troxipide hydrochloride to the reaction vessel with chloroform, stirring and heating, filtering, washing filter cake, and decompression drying; and adding troxipide crude product with alcohol, stirring and heating, clarifying, hot filtering, collecting filter liquid, cooling filtered liquid, crystallizing, filter cake washing, and vacuum drying to obtain the troxipide.    USE - Method for preparing troxipide (claimed).    ADVANTAGE - The method can prepare troxipide having special quality, high purity, simple preparation method, low energy consumption and low cost.    DETAILED DESCRIPTION - Preparation of troxipide comprises:    (A) adding 3,4,5-Trimethoxy-N-pyridin-3-yl-benzamide hydrochloride and water in an autoclave, heating at 35-40 degrees C, stirring the reaction until the reactant dissolved and clarified, carrying out heat preservation, adding palladium carbon catalyst, filling 0.8 MPa, warming to 85-90 degrees C, keeping the temperature for supplementing to 5 MPa, stirring up the hydrogen reaction, stopping the reaction when the detection of residual materials is less than or equal to 0.5%, and filtering the reaction mixture to give hydrochloride hydrogenation liquid;    (B) adding troxipide hydrochloride to the reaction vessel with chloroform, stirring and heating at 35-40 degrees C, adjusting pH to 7.4-7.5, preserving heat, adding diatomite, stirring, keeping the temperature, filtering, standing the filtered liquid and layering, oil removing of the lower layer and the upper aqueous layer and adding trichloromethane at room temperature, stirring and heating at 35-40 degrees C, incubating under conditions adjusted to pH 7.4-7.5, stirring until solution clarification, then continue to the adding in diatomite, stirring, keeping the temperature, filtering, standing the filtered liquid and layering, retaining the lower oil layer and then the upper water layer and adding chloroform at room temperature, stirring at room temperature after layering, retaining the lower oil layer and then aqueous layer and adding trichloromethane, stirring at room temperature and layering, taking oil layer, a combining layer oil, normal pressure concentrate, cooling to 5 degrees C, cooling and crystallizing after decompressing filtering, washing filter cake, and decompression drying to obtain a special troxipide crude product; and    (C) adding troxipide crude product with alcohol to reaction container, stirring and heating up to reflux, then maintaining reflux under stirring to dissolve the reactant to reaction liquid, clarifying, hot filtering, collecting filter liquid, cooling filtered liquid to 5 degrees C to crystallize, crystallizing after filtering, filter cake washing, and vacuum drying to obtain the troxipide.