NOVELTY - Production of a lipoxin derivative, comprises contacting a ethyl propiolate with a lithium bromide base in the presence of acetic acide (HOAC) in methyl cyanide (CH3CN).    USE - The method is useful for producing a lipoxin derivative (claimed) used as an anti-inflammatory agent.    ADVANTAGE - The method has improved yield of lipoxin derivative, mild reaction conditions, environment-friendly and provides a reliable synthesis process.    DETAILED DESCRIPTION - Production of a lipoxin derivative of Formula (19), comprises contacting a ethyl propiolate with a lithium bromide base in the presence of acetic acid (HOAC) in methyl cyanide (CH3CN) to obtain the compound of Formula (2); contacting a compound of Formula (3) with n-BuLi bromocyclane in tetrahydrofuran (THF) to obtain a compound of Formula (4); contacting the compound of Formula (4) with HZrCp2Cl in THF to obtain a compound of Formula (5); contacting the compound of Formula (2) with the compound of Formula (4) in the presence of Pd(PPh3)2Cl2, diisobutylaluminum hydride (DIBAH) and zinc chloride (ZnCl2) to obtain a compound of Formula (6); contacting the compound of Formula (6) with DIBAL in dichloromethane (DCM) to obtain a compound of Formula (7); contacting the compound of Formula (7) with carbon tetrabromide (CBr4), triphenylphosphine (PPh3), imidazole in DCM to obtain a compound of Formula (8); contacting the compound of Formula (8) with trimethyl phosphate (P(OMe)3) in CH3CN to obtain a compound of Formula (9); contacting the compound of Formula (10) with acetyl chloride in methyl hydroxide (MeOH) under room temperature to obtain a compound of Formula (11); contacting compound of Formula (11) with carbonyldiimidazole (CDI) in CH3CN under a condition of refluxing to obtain a compound of Formula (12); contacting the compound of Formula (12) with hydrochloric acid (HCl) in a mixture of dioxane and water under a condition of refluxing to obtain a compound of Formula (13), where the volume ratio of dioxane to water is about 3:1; contacting the compound of Formula (13) with Ph3PCHCO2 and benzolic acid in toluene under a condition of refluxing to obtain a compound of Formula (14); contacting the compound of Formula (14) with H2 in the presence of palladium (Pd)/carbon (C) in ethanol (EtOH) to obtain a compound of Formula (15); contacting the compound of Formula (15) with dicyclohexylcarbodiimide (DCC), and Cl2CHCOOH to obtain a compound of Formula (16); contacting the compound of Formula (16) with Ph3P=CHCHO in DCM to obtain a compound of Formula (17); contacting the compound of Formula (17) with the compound of Formula (9) in the presence of lithium diisopropylamide (LDA) and hexamethylphosphoramide (HMPA) in THF to obtain a compound of Formula (18); and contacting the compound of Formula (18) with sodium hydroxide (NaOH) in MeOH to obtain the compound of Formula (19), where the reaction is represented by Reaction Scheme I.    n=1-5.    INDEPENDENT CLAIMS are included for:    (1) a method of producing a CO2Et-containing compound of Formula (6), which comprises contacting a bromide-containing compound of Formula (2) with a bis(triphenylphosphine) palladium(II) chloride and diisobutylaluminum hydride to obtain the compound of Formula (6); and    (2) a method of producing a COOEt-containing compound of Formula (14) which comprises: contacting a compound of Formula (13) with ethyl(triphenylphosphoranylidene)acetate and enzolic acid to obtain the compound of Formula (14).