NOVELTY - Preparation of pramiracetam sulfate involves reacting N-((2-diisopropylamino)ethyl)-chloroacetamide, pyrrolidone and sodium hydroxide at 60-70 degrees C for 20-30 hours, extracting with purified water and dichloromethane, drying organic phase with anhydrous sodium sulfate, filtering, concentrating at 35-40 degrees C under reduced pressure to obtain pramiracetam, reacting pramiracetam with concentrated sulfuric acid at 0-5 degrees C for 2-6 hours, filtering, drying at 55-60 degrees C, dissolving crude pramiracetam sulfate in ethanol, crystallizing at 0-5 degrees C, filtering, and drying at 55-60 degrees C.    USE - Preparation of pramiracetam sulfate (claimed).    ADVANTAGE - The method is environmentally-friendly, and enables efficient and economical preparation of pramiracetam sulfate with reduced organic material discharge, by simple method.    DETAILED DESCRIPTION - Preparation of pramiracetam sulfate involves cooling thionyl chloride to 0-5 degrees C, adding N,N-diisopropylamine, heating to 75-80 degrees C, reacting for 8-12 hours, cooling to 30-40 degrees C, adding methanol, stirring at 55-60 degrees C under reduced pressure, adding mixed solvent of ethanol/isopropyl ether in volume ratio of 1:10, stirring at 0-5 degrees C, crystallizing for 10 hours, filtering, vacuum-drying at 50-660 degrees C to obtain N,N-diisopropyl-2-chloro-ethylamine hydrochloride, reacting N,N-diisopropyl-2-chloro-ethylamine hydrochloride with ammonia at 5-10 degrees C for 6-10 hours, adding methylene chloride, extracting using 5% sodium hydroxide solution and saturated sodium chloride solution, collecting organic layer, drying with anhydrous sodium sulfate, filtering, concentrating at 40-45 degrees C under reduced pressure to obtain N,N-diisopropyl ethylenediamine, adding chloroacetyl chloride and N,N-diisopropyl ethylenediamine in toluene solvent, reacting in presence of sodium carbonate at 20-35 degrees C for 2-6 hours, extracting with saturated sodium chloride solution, to obtain N-((2-diisopropylamino)ethyl)-chloroacetamide, reacting N-((2-diisopropylamino)ethyl)-chloroacetamide, pyrrolidone and sodium hydroxide at 60-70 degrees C for 20-30 hours, extracting with purified water and dichloromethane, drying organic phase with anhydrous sodium sulfate, filtering, concentrating at 35-40 degrees C under reduced pressure to obtain pramiracetam, reacting pramiracetam with concentrated sulfuric acid at 0-5 degrees C for 2-6 hours, filtering, drying at 55-60 degrees C, dissolving crude pramiracetam sulfate in ethanol, crystallizing at 0-5 degrees C, filtering, and drying at 55-60 degrees C. The molar ratio of N,N-diisopropyl amine with thionyl chloride is 1.5-2. The weight ratio of methanol and thionyl chloride is 0.10-0.15. The molar ratio of N,N-diisopropyl-2-chloro-ethylamine hydrochloride and ammonia is 1:10-1:20. The weight ratio of methylene chloride and N,N-diisopropyl-2-chloro-ethylamine hydrochloride is 4-5. The molar ratio of N,N-diisopropyl ethylenediamine and chloroacetyl chloride is 0.8-1. The molar ratio of pyrrolidone and sodium hydroxide with respect to N-((2-diisopropylamino)ethyl)-chloroacetamide is 1-2.