NOVELTY - A ticagrelor monohydrate comprises 1 pt. wt. water, belongs to orthorhombic system, and has F222NO.22 space group, and cell parameter values a of 14.277(2) Angstrom , b of 22.209(3) Angstrom , c of 34.277(6) Angstrom , and alpha , beta and gamma of 90.00 degrees , and exhibits two large endothermic peaks at 102 plus minus 5 degrees C and 136 plus minus 5 degrees C in differential scanning calorimetry spectrum and characteristic diffraction peak in diffraction angle (2( theta ) plus minus 0.1) of 5.1 degrees , 7.8 degrees , 9.5 degrees , 10.7 degrees , 13.4 degrees , 14.8 degrees , 15.5 degrees , 17.4 degrees , 19.2 degrees , 19.5 degrees , 20.7 degrees , 20.9 degrees , 21.1 degrees , 21.4 degrees and 22.4 degrees , measured in X-ray powder diffraction pattern.    USE - Ticagrelor monohydrate is useful in pharmaceutical composition and in preparation of drug for preventing or treating thrombosis (all claimed).    ADVANTAGE - The ticagrelor monohydrate has excellent storage stability and water solubility, and is prepared by a simple process. The solvent used in the preparation method is environmentally-friendly and easy to recycle and reuse.    DETAILED DESCRIPTION - A ticagrelor monohydrate comprises 1 pt. wt. water, and belongs to orthorhombic system, and has F222NO.22 space group and cell parameter values a of 14.277(2) Angstrom , b of 22.209(3) Angstrom , c of 34.277(6) Angstrom , alpha , beta and gamma of 90.00 degrees , volume of 10868(3) Angstrom 3 and Z molecule/unit cell of 16, and exhibits two large endothermic peaks at 102 plus minus 5 degrees C and 136 plus minus 5 degrees C in differential scanning calorimetry spectrum and characteristic diffraction peak in diffraction angle (2( theta ) plus minus 0.1) of 5.1 degrees , 7.8 degrees , 9.5 degrees , 10.7 degrees , 13.4 degrees , 14.8 degrees , 15.5 degrees , 17.4 degrees , 19.2 degrees , 19.5 degrees , 20.7 degrees , 20.9 degrees , 21.1 degrees , 21.4 degrees and 22.4 degrees , measured in X-ray powder diffraction pattern. The ticagrelor monohydrate is in crystal form and of formula: C23H28F2N604SH2O. An INDEPENDENT CLAIM is included for preparation of ticagrelor monohydrate, which involves adding ticagrelor in mixed solvent of organic solvent and water, dissolving by heating, cooling, crystallizing, filtering and drying.