NOVELTY - A genetically modified microorganism comprising genetic modifications involving one or more (or any combination) target genes encoding (a) putrescine-ornithine antiporter (PotE), (b) putrescine importer (PuuP), (c) ATP-dependent polyamine transporter (PotABCD), and (d) low affinity putrescine-importer (PlaP), or (e) isolated microorganism chosen from EMFR9 or EMFR35, or (f) microbial cell comprising an increased copy number of a puuP gene or transcripts of gene and/or an increased copy number of a potE gene or transcripts of gene, is new.    USE - The microorganism useful for producing desired products chosen from ethanol, lactic acid, succinic acid, malic acid, acetic acid, 1,3-propanediol, 2,3-propanediol, 1,4-butanediol, 2,3-butanediol, butanol, pyruvate, dicarboxylic acids, adipic acid, and amino acids (all claimed).    ADVANTAGE - The microorganism exhibits increased production of desired product in the presence of furfural and/or 5-HMF as compared the production of the desired product by a reference microorganism in the presence of furfural and/or 5-HMF, and provides expression of polyamine transporter genes and/or polyamine supplements to increase furfural tolerance in microorganisms.    DETAILED DESCRIPTION - A genetically modified microorganism comprising genetic modifications involving one or more (or any combination) target genes encoding (a) putrescine-ornithine antiporter (PotE), (b) putrescine importer (PuuP), (c) ATP-dependent polyamine transporter (PotABCD), and (d) low affinity putrescine-importer (PlaP), where the genetic modifications cause increased expression and/or activity of the polypeptides produced by target genes, or (e) isolated microorganism chosen from EMFR9 or EMFR35, or (f) microbial cell comprising an increased copy number of a puuP gene or transcripts of gene and/or an increased copy number of a potE gene or transcripts of gene, is new. INDEPENDENT CLAIMS are included for the following:    (1) method (M1) for producing a desired product from a biomass, involves contacting the biomass with the microorganism, and producing the desired product by fermenting the biomass in the presence of the microorganism;    (2) method (M2) for increasing furfural and/or 5-HMF resistance in a microorganism, involves introducing in to the microorganism genetic modifications, and culturing the microorganism in the presence of one or more polyamines; and    (3) composition comprising a microorganism and culture medium.