NOVELTY - Chalcone compound is prepared by reacting 1,9-diazatetracyclo(7.7.1.02,7.010,15)heptadeca-2(7),3,5,10(15),11,13-hexaene-5,13-dicarbaldehyde (I) with 2-hydroxyacetophenone compound (II), in sodium hydroxide and anhydrous ethanol, cooling to room temperature, adding ice water, adjusting pH using hydrochloric acid, filtering, washing the resultant product with water, purifying filter cake by column chromatography using petroleum ether and ethyl acetate in volume ratio of 2:1, obtaining chalcone compound (III).    USE - Synthesis of diazatetracyclo-heptadeca-hexaene derivative e.g. chalcone compound, flavanone and benzimidazole compound used in anti-cancer drug.    ADVANTAGE - The method enables simple, economical, efficient, environmentally-friendly and convenient synthesis of diazatetracyclo-heptadeca-hexaene derivative having high human liver cancer HepG2 cell resisting activity with high yield under mild reaction conditions.    DETAILED DESCRIPTION - Chalcone compound is prepared by reacting 1,9-diazatetracyclo(7.7.1.02,7.010,15)heptadeca-2(7),3,5,10(15),11,13-hexaene-5,13-dicarbaldehyde of formula (I) with 2-hydroxyacetophenone compound of formula (II), in sodium hydroxide and anhydrous ethanol, cooling to room temperature, adding ice water, adjusting pH using hydrochloric acid, filtering, washing the resultant product with water, purifying filter cake by column chromatography using petroleum ether and ethyl acetate in volume ratio of 2:1, obtaining chalcone compound of formula (III), or reacting 13-bromo-1,9-diazatetracyclo(7.7.1.02,7.010,15)heptadeca-2(7),3,5,10(15),11,13-hexaene-5-carbaldehyde of formula (IV) with compound (II) in sodium hydroxide and anhydrous ethanol, cooling to room temperature, adding ice water, adjusting pH using hydrochloric acid, filtering, washing the resultant product with water, purifying filter cake by column chromatography using petroleum ether and ethyl acetate in volume ratio of 2:1, obtaining chalcone compound of formula (V), or reacting 4-(13-(4-formylphenyl)-1,9-diazatetracyclo(7.7.1.02,7.010,15)heptadeca-2(7),3,5,10(15),11,13-hexaen-5-yl)benzaldehyde and substituted hydroxyacetophenone compounds in sodium hydroxide and anhydrous ethanol, cooling to room temperature, adding ice water, adjusting pH using hydrochloric acid, filtering, washing the resultant product with water, purifying filter cake by column chromatography using petroleum ether and ethyl acetate in volume ratio of 2:1, obtaining chalcone compounds of formulae (VI) or (VI). The flavanone is prepared by dissolving compound (V) in ethanol, adding sodium acetate, stirring, cooling to room temperature, adding water, filtering, purifying filter cake by column chromatography using petroleum ether and ethyl acetate in volume ratio of 4:1, obtaining flavanone compound of formula (VIII), or dissolving compound (V) in dimethyl sulfoxide, cooling to room temperature, adding water, filtering, purifying filter cake by column chromatography using petroleum ether and ethyl acetate in volume ratio of 2:1, obtaining flavanone compound of formula (IX). The benzimidazole compound is prepared by adding dichloromethane to compound (VI) and silicon sulfoacid, stirring, and carrying out column chromatography using petroleum ether and ethyl acetate in volume ratio of 1:1, and obtaining benzimidazole compound of formula (X). The obtained compounds are measured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against human hepatoma HepG2 cell activity.    R=4-OCH3, 5-CH3 or 5-OCH3;    R'=5-CH3 or 5-OCH3;    R1=5-OCH3;    R2=H;    R"=5-CH3;    R3=4-OCH3 or 5OCH3;and    R4,R5=H, 4-CH3 or 4-Br.