NOVELTY - Preparing high-purity clindamycin phosphate powder injection comprises: (i) adding clindamycin phosphate crude product, anhydrous ethanol and purified water into a dissolution tank, heating, decolorizing and carrying out sterile filtration; (ii) adding the filtrate into a crystallization tank; (iii) carrying out centrifugal separation and washing with ethanol; (iv) pouring the clindamycin phosphate into a dryer, cooling and warming to obtain clindamycin phosphate sterile crude powder; and (v) sieving the crude powder under laminar air flow protection, aliquoting into sterile vials and capping.    USE - The method is useful for preparing high-purity clindamycin phosphate powder injection (claimed).    ADVANTAGE - The product has high purity with little impurity, chemical stability and high solubility. The method is simple, economical, utilizes less solvent and environmentally-friendly.    DETAILED DESCRIPTION - Preparing high-purity clindamycin phosphate powder injection comprises: (i) adding clindamycin phosphate crude product, anhydrous ethanol and purified water (in a weight ratio of 1:2-6:2) into a dissolution tank, heating to 70-75 degrees C for complete dissolution, decolorizing with activated coal and carrying out sterile filtration; (ii) adding the filtrate into a crystallization tank for crystallizing; (iii) carrying out centrifugal separation of crystallized product, then washing with ethanol (weight ratio of crude product and ethanol is 1:1-2); (iv) pouring the washed clindamycin phosphate into a dryer, setting the vacuum gauge to less than or equal to -0.098 MPa, cooling for 1-1.5 hour, warming to 60-75 degrees C, drying for 1-2 hours, raising the temperature again to 80-85 degrees C, drying for 6-8 hours, finally raising the temperature to 90-95 degrees C, drying for 3-5 hours, cooling for 1-1.5 hour to obtain clindamycin phosphate sterile crude powder; and (v) sieving the clindamycin phosphate sterile crude powder under laminar air flow protection, aliquoting into sterile vials, capping with butyl rubber plug and rolling with aluminum cover. An INDEPENDENT CLAIM is also included for high-purity clindamycin phosphate powder injection, comprising clindamycin phosphate as active component with anhydrous weight percentage of not less than 78 wt.%.