NOVELTY - Preparing loxoprofen sodium intermediate i.e. substituted 2-(4-(chloromethyl)phenyl)propanoic acid compound (I) comprises (i) carrying out Friedel-crafts acylation of benzene with propionanilide to obtain propiophenone, (ii) halogenating to obtain 2-halo-propiophenone, (iii) ketalizing 2-halo-propiophenone with diol type compound to obtain ketal intermediate (II), (iv) carrying out rearrangement and hydrolysis of (II) to obtain 2-phenylpropionic acid, (v) esterifying with alcohol to obtain substituted 2-phenylpropionate compound (III), and (vi) chloromethylating (III) to obtain final product.    USE - The method is useful for preparing loxoprofen sodium intermediate (claimed).    ADVANTAGE - The method utilizes easily available raw materials; has high yield, and is simple, environment-friendly and suitable for industrial production.    DETAILED DESCRIPTION - Preparing loxoprofen sodium intermediate i.e. substituted 2-(4-(chloromethyl)phenyl)propanoic acid compound of formula (I) comprises (i) carrying out Friedel-crafts acylation of benzene with propionanilide reagent to obtain propiophenone, (ii) carrying out halogenation of propiophenone with halogenating reagent to obtain 2-halo-propiophenone, (iii) carrying out ketalization reaction of 2-halo-propiophenone with diol type compound to obtain ketal intermediate of formula (II), (iv) carrying out rearrangement and hydrolysis of (II) to obtain 2-phenylpropionic acid, (v) esterifying 2-phenylpropionic acid with an alcohol to obtain substituted 2-phenylpropionate compound of formula (III), and (vi) carrying out chloromethylation of (III) with chloromethylation reagent to obtain final product.    n=0 or 1;    R1, R2=H, CH3 or CH2CH3;    X=Cl or Br; and    R=1-5C alkyl.    An INDEPENDENT CLAIM is also included for preparation of loxoprofen sodium comprises (a) taking above obtained loxoprofen sodium intermediate, (b) carrying out condensation by reacting sodium loxoprofen intermediate with 2-methoxycarbonyl cyclopentanone to obtain 2-(4-(1-methoxycarbonyl-2-oxo-1-cyclopentyl-ylmethyl)phenyl)propionate, (c) carrying out decarboxylation of 2-(4-(1-methoxycarbonyl-2-oxo-1-cyclopentyl-ylmethyl) phenyl) propionate under acidic conditions to obtain 2-(4-(1-methoxycarbonyl-2-oxo-1-cyclopentyl-ylmethyl)phenyl)propionic acid, and (d) carrying out salt formation reaction by reacting 2-(4-(1-methoxycarbonyl-2-oxo-1-cyclopentyl-ylmethyl)phenyl)propionic acid with base to obtain final product.