NOVELTY - Extracting mogroside V from fructus momordicae comprises cleaning fresh fructus momordicae, high pressure micro-jet ultrafine crushing, adding pure water, processing in a high speed shearing emulsifying machine, high pressure micro-jet ultrafine crushing to obtain a pasty slurry, extracting in an extraction kettle by taking supercritical carbon dioxide fluid as an extraction solvent and ethanol solution as a cosolvent, collecting the extract, centrifuging, processing the supernatant by HP-20SS resin column chromatography, eluting with ethanol, concentrating eluate and spray drying.    USE - The method is useful for extracting mogroside V from fructus momordicae (claimed).    ADVANTAGE - The method has high yield; is simple, economical, minimally polluting and suitable for large-scale production. The method avoids the use of large amounts of organic solvents, making it environmentally friendly.    DETAILED DESCRIPTION - Extracting mogroside V from fructus momordicae comprises (a) cleaning fresh fructus momordicae and crushing, (b) high pressure micro-jet ultrafine crushing, adding pure water into fructus momordicae slurry in a weight ratio of 1:8-10, processing in a high speed shearing emulsifying machine for 10-20 minutes at a speed of 8000-12000 revolutions/minute, high pressure micro-jet ultrafine crushing at 25 degrees C at a pressure of 80-120 MPa for 2-4 times to obtain a pasty slurry, (c) placing the slurry in an extraction kettle, taking supercritical carbon dioxide fluid as an extraction solvent and 50-60% ethanol solution as a cosolvent for supercritical extraction, where the mass to volume ratio of the slurry and the extraction kettle is 1:4, the volume ratio of the ethanol solution and extraction kettle is 1:2, extracting at 50-60 degrees C at a pressure of 15-20 Mpa for 5-2 hours, and (d) collecting the extraction liquid, centrifuging, processing the supernatant by HP-20SS resin column chromatography, eluting with 50-60% ethanol solution, concentrating eluate and spray drying.