NOVELTY - Amphiphilic nanosheet is made which involves appending functional groups to a stack of lamellar crystals; and exfoliating the stack of lamellar crystals to form the amphiphilic nanosheets. The functional groups comprise octadecyl isocyanate. The nanosheets comprise at least two regions, where the first region is hydrophilic, and where the second region is hydrophobic.    USE - The method is useful for making amphiphilic nanosheet (claimed). The amphiphilic nanosheets are used as surfactants, paints, cosmetic products, pharmaceutical products, detergents, emulsions, foam stabilizers, rheological thickeners for drilling fluids, coating agents, as alignment agents for biomolecules in magnetic fields using NMR to measure the structure of the biomolecules, and used as smart devices. Additionally, the amphiphilic nanosheets can be used as surfactants for enhanced oil recovery, such as emulsifiers in microfluidic channels and reservoir rocks (e.g. porous rocks). The amphiphilic nanosheet can also be used for stabilizing contrast agents for ultrasonic imaging of colloids, such as gas bubbles; for enhancing stability of high expansion foam; and for fire extinguishing of liquefied natural gas (LNG); for coating or cleaning solar cells; for delivering drugs, genes, and other compounds to a desired site in an organism (e.g., a human patient); and for making luminescent, conductive or semi conductive materials.    ADVANTAGE - The method provides a facile and continuous method of making bulk quantities of Janus and Gemini particles. The amphiphilic nanosheets (such as alpha -zirconium phosphate platelets) have established a platform for flexible design of multifunctional surfactants tailored for optimal performance. In particular, the highly anisotropic and amphiphilic nanosheets reconcile the opposite effects (in the stabilization of Pickering emulsions (emulsions stabilized by particles) using spherical particles) due to the existence of length scales, thicknesses, and lateral size (2Rd). The large aspect ratios of the amphiphilic nanosheets also offer optimal stability to the nanosheets between two emulsions to prevent coalescence. Likewise, the nanosheet's large lateral surface area offers strong adsorption energy at the oil-water interface.