NOVELTY - Manufacturing zaltoprofen, comprises e.g. performing rearrangement reaction of 5-(1-propionyl)-2-phenylthio-phenylacetic acid in presence of e.g. cuprous oxide catalyst and iodine by heating, stirring, cooling reaction kettle, adding sodium thiosulfate aqueous solution, stirring, extracting using ethyl acetate, combining ethyl acetate phase, washing ethyl acetate phase, evaporating ethyl acetate to obtain intermediate I, adding ethanol and alkali solution into obtained intermediate I, refluxing, neutralizing with hydrochloric acid, and extracting reaction solution with ethyl acetate.    USE - The method is useful for manufacturing zaltoprofen (claimed).    ADVANTAGE - The method reduces the activation energy required for the reaction and impact of the rearrangement reaction on methyl iodide; has high reaction efficiency and higher yield; sublimates iodine into gaseous form; ensures sufficient contact of gaseous iodine with the substrate; and is less time consuming thus quickly complete the reaction and suitable for industrial production. The process is environmentally friendly.    DETAILED DESCRIPTION - Manufacturing zaltoprofen, comprises (a) performing rearrangement reaction of 5-(1-propionyl)-2-phenylthio-phenylacetic acid in the presence of cuprous oxide catalyst, iodine and triethyl orthoformate by continuously heating under light condition at 55 degrees C , and stirring for 2-5 hours, (b) cooling the reaction kettle to room temperature, adding sodium thiosulfate aqueous solution, continuously stirring for 2-5 hours, extracting using ethyl acetate, combining ethyl acetate phase, washing ethyl acetate phase, and evaporating ethyl acetate to obtain intermediate I, (c) adding ethanol and alkali solution into the obtained intermediate I, refluxing for 1-5 hours, neutralizing with hydrochloric acid, extracting the reaction solution with ethyl acetate, combining ethyl acetate phase, washing ethyl acetate phase, drying, adding n-hexane, and precipitating the crystals to obtain intermediate II, (d) mixing polyphosphoric acid and phosphoric acid with the obtained intermediate II, reacting by heating at 80-90 degrees C for 22-26 hours, placing reaction kettle in ice water, stirring, filtering to obtain solid, dissolving the obtained solid in dichloromethane, successively washing with sodium bicarbonate solution, neutralizing the pH using saline solution, drying, vacuum concentrating the solvent until 1/3- one quarter of the initial volume of the concentrate is obtained, cooling, crystallizing, and filtering to obtain crude zaltoprofen, and (e) adding methylene chloride to the obtained obtain crude zaltoprofen, heating, decolorizing using activated carbon, filtering while in hot state, crystallizing, precipitating, and suction filtering.