NOVELTY - Progesterone is synthesized by adding 4-androstenedione and ether solvent into reactor, stirring, dissolving, adding acetone cyanohydrin and organic amine, reacting at 20-60 degrees C for 10-48 hours, adding saturated ammonium chloride solution, stirring for 0.2-2 hours, standing, layering, removing aqueous layer, washing with saturated ammonium chloride for 3-6 times, neutralizing pH, adding triethyl orthoformate, stirring, adding anhydrous ethyl alcohol and p-toluenesulfonic acid, reacting for 1-5 hours, and adding aqueous potassium carbonate solution and saturated sodium chloride solution.    USE - Synthesis of progesterone (claimed).    ADVANTAGE - Process is low cost and environment-friendly, and product has high yield.    DETAILED DESCRIPTION - Progesterone is synthesized by adding 4-androstenedione and ether solvent into reactor, stirring, dissolving, adding acetone cyanohydrin and organic amine, reacting at 20-60 degrees C for 10-48 hours, adding saturated ammonium chloride solution, stirring for 0.2-2 hours, standing, layering, removing aqueous layer, washing with saturated ammonium chloride for 3-6 times, neutralizing pH, adding triethyl orthoformate, stirring, adding anhydrous ethyl alcohol and p-toluenesulfonic acid, reacting for 1-5 hours, adding aqueous potassium carbonate solution and saturated sodium chloride solution, stirring, standing, layering, removing aqueous organic layer, adding butyl vinyl ether and p-toluenesulfonic acid, stirring, reacting for 0.5-5 hours, adding Grignard reagent, heating at 60-90 degrees C for 5-48 hours under reflux condition, elutriating with ice water, adding hydrochloric acid, hydrolyzing, cooling to room temperature, filtering, drying to obtain crude 17- alpha -hydroxyprogesterone, adding crude 17- alpha -hydroxyprogesterone and pyridine or dimethylpyridine into reaction flask, stirring, dissolving, adding halogenating agent and sulfur dioxide in pyridine solution at 0 degrees C, reacting at - 15-5 degrees C for 3-6 hours under nitrogen protection, elutriating with ice water, filtering, drying, refining, placing refined material into reaction flask, adding polar solvent, stirring, dissolving, adding palladium on carbon, catalytic blocker, and cyclohexene, reacting at 40-120 degrees C for 2-8 hours, filtering, concentrating under reduced pressure, adding water, elutriating, filtering, drying, and refining.