NOVELTY - Florfenicol supramolecular preparation comprises 5-10 pts. wt. florfenicol, 5-20 pts. wt. soybean separated protein, 5-20 pts. wt. maltodextrin, 10-40 pts. wt. ethyl alcohol-pure water (1:1), and 20-80 pts. wt. glucose, sucrose powder (80 meshes) or hydroxypropyl methylcellulose.    USE - Used as florfenicol supramolecular preparation.    ADVANTAGE - The preparation has bioavailability. The method has economical process and high production efficiency, is safe and environmentally friendly, has good repeatability, can be mixed with feed and drink, is convenient to use, and is welcomed by majority of farmers.    DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for preparing florfenicol supramolecular preparation comprising (i) preparing materials: providing florfenicol, soybean separated protein, maltodextrin, ethyl alcohol-pure water (1:1), glucose or sucrose powder (80 meshes) or hydroxypropyl methylcellulose, (ii) dissolving soybean separated protein and dextrin in 5-10 times of pure water, heating to 50-70 degrees C for 40-60 minutes, stirring to form super-molecule object which is soybean separated protein and maltodextrin grafted polymer, (iii) adding dispersed solvent, stirring to uniform dispersion, colloid mill thinning through 300 meshes, and forming liquid, (iv) adding step (iii) obtained florfenicol liquid and step (ii) soybean separated protein and maltodextrin grafted polymer in a reaction kettle, ultrasonically processing for 200-1000 KW for 30-60 minutes to form chimeric florfenicol soybean separated protein-maltodextrin grafted polymer super-micro-emulsion, (v) drying super-molecule micro-emulsion under reduced pressure at 50-60 degrees C for 2-4 hours, and preparing florfenicol supramolecule, and (vi) adding auxiliary material glucose or sucrose powder (80 meshes) or hydroxypropyl methyl cellulose in florfenicol supramolecule, preparing super-molecule particles, drying at 50-60 degrees C under reduced pressure for 1-2 hours, sieving via 40 meshes to whole grain, to obtain super-molecule preparation, and completing process.