NOVELTY - (R)-9-(2-(Diethyl phosphorylmethoxy)propyl)adenine is dissolved in acetonitrile, and bromotrimethylsilane is added, to obtain (R)-9-(2-phosphate-methoxypropyl)adenine (crude tenofovir hydrate). Crude tenofovir hydrate is added to purified water and heated. Organic solvent is added, crystallized and dried, to obtain pure tenofovir hydrate. N,N-Dimethylformamide and chloromethyl isopropyl carbonate are added to obtained tenofovir and reacted. Isopropanol and fumaric acid are added to obtained tenofovir topiramate furosemide ester, to obtain fumarate tenofovir topiramate furosemide ester.    USE - Preparation of fumarate tenofovir topiramate furosemide ester (claimed).    ADVANTAGE - The method enables economical and environmentally-friendly preparation of fumarate tenofovir topiramate furosemide ester with high purity and yield and low generated waste amount and without side effects, by simple method.    DETAILED DESCRIPTION - (R)-1,2-Propanediol, catalyst (c1) and carbonate (n1) are dissolved in solvent (s1), stirred, reacted and the completion of reaction is detected by thin-layer chromatography method. The solvent (s1) is distilled off from the mixture, to obtain (R)-4-methyl-1,3-dioxolan-2-one. (R)-4-Methyl-1,3-dioxolan-2-one, adenine and basic catalyst (c2) are added to N,N-dimethylformamide and reacted, and the completion of reaction is detected by thin-layer chromatography method. The solvent (s2) is distilled off from the mixture, to obtain (R)-9-(2-hydroxypropyl)adenine. (R)-9-(2-Hydroxypropyl)adenine is added to reactor, and metal alkoxide, N,N-dimethylformamide and toluene are added to reactor, and acyloxymethyl phosphate is dripped and reacted, and the completion of reaction is detected by thin-layer chromatography method. The pH of mixture is adjusted to 6-7, and solvent (s3) is distilled off from the mixture, and dichloromethane is added and reacted, to obtain (R)-9-(2-(diethyl phosphorylmethoxy)propyl)adenine. (R)-9-(2-(Diethyl phosphorylmethoxy)propyl)adenine is dissolved in acetonitrile, and bromotrimethylsilane is added, and the completion of reaction is detected by thin-layer chromatography method. The mixture is concentrated to dryness and dissolved in water. The pH of mixture is adjusted with alkaline reagent to 2.8-3.8, and the obtained filter cake is added to predetermined amount of purified water, and pH of mixture is adjusted with alkaline reagent to 5-6 and filtered. The pH of filtrate is adjusted with acidic reagents to 3-4, to obtain (R)-9-(2-phosphate-methoxypropyl)adenine (crude tenofovir hydrate). Crude tenofovir hydrate is added to predetermined amount of purified water and heated. Predetermined amount of an organic solvent is added, crystallized and dried, to obtain pure tenofovir hydrate. Predetermined amount of pure hydrocarbon solvent is added to pure hydrate tenofovir, heated under reflux, and water is removed from tenofovir hydrate pure, to obtain tenofovir. N,N-Dimethylformamide, acid binding agent and chloromethyl isopropyl carbonate are added to tenofovir, reacted, filtered and dried, to obtain tenofovir topiramate furosemide ester. Isopropanol and fumaric acid are added to tenofovir topiramate furosemide ester, to obtain fumarate tenofovir topiramate furosemide ester.