NOVELTY - Culturing oxytetracycline-tolerance anaerobic ammonium oxidation granular sludge culture, comprises (i) adding anaerobic ammonia oxidation grain sludge as inoculating source into a flow-type anaerobic sludge bed reactor, taking wastewater influent containing ammonia and nitrite nitrogen, carrying out anaerobic reaction under dark conditions, carrying out hydraulic retention time (HRT) culture in reactor under stable conditions; and (ii) culturing once the microbial activity in the reactor initial runtime inoculated granular sludge anaerobic ammonium oxidation activity reaches 2-3 times.    USE - The method is useful for culturing oxytetracycline-tolerance anaerobic ammonium oxidation granular sludge culture (claimed).    DETAILED DESCRIPTION - Culturing oxytetracycline-tolerance anaerobic ammonium oxidation granular sludge culture, comprises (i) adding anaerobic ammonia oxidation grain sludge as inoculating source into a flow-type anaerobic sludge bed reactor, taking wastewater influent containing ammonia and nitrite nitrogen, carrying out anaerobic reaction under dark conditions at 35 plus minus 1?OC, where the influent pH is 8.10 plus minus 0.14, carrying out hydraulic retention time (HRT) culture in the reactor under stable conditions for 0.8-2.5 hours, to obtain precipitate, adding water slowly into oxytetracycline continued to culture until the reactor running for some time after the reactor microbial activity, once the oxytetracycline activity terminates in culture for the first time; and (ii) supplementing granular sludge anaerobic ammonia oxidation in reactor, and culturing once the microbial activity in the reactor initial runtime inoculated granular sludge anaerobic ammonium oxidation activity reaches 2-3 times, to obtain the product, where the wastewater includes 70-280 mg/l ammonia nitrogen, 70-280 mg/l nitrite, 5-20 mg/l monopotassium phosphate, 1-10 mg/l calcium chloride dehydrate, 200-400 mg/l magnesium sulfate dihydrate, 800-1500 mg/l potassium bicarbonate and solvent, preferably water.    DESCRIPTION OF DRAWING(S) - The drawing shows a schematic representation of the flow-type anaerobic sludge bed reactor.