NOVELTY - Preparing substituted 2-pyrrol-1-yl-propane-1,3-diol compounds (I), comprises: (a) reacting substituted succinaldehyde (II) with 2-amino-propane-1,3-diol (III) without solvents and/or organic diluents to form an intermediate hexahydro-1,4-dioxa-6b-aza-cyclopenta(cd)pentalene (IV); and (b) converting (IV) to (I) by heating the reaction mixture to a temperature of 100-200 degrees C for 1-500 minutes, or by adding a carbon allotrope or its derivatives.    USE - The process is useful for preparing (I) (claimed), which are useful as antimalarial, anti-inflammatory, anti-asthma, bactericidal, and antihypertensive agents. No biological data given.    ADVANTAGE - The process: performs the step (a) without using solvents and/or organic diluents, acids (all claimed) and chemical catalysts; does not generate polluting waste products, hence eliminates the further phases of purification and separation from the byproducts; provides (I) with high yield and purity with a minimal energy consumption, hence it is simple, cost effective and environmental friendly; and provides a stable reaction intermediate that is easy to prepare, preserve and store without difficulty before completing the preparation process.    DETAILED DESCRIPTION - Preparing substituted 2-pyrrol-1-yl-propane-1,3-diol compounds of formula (I), comprises: (a) reacting substituted succinaldehyde of formula (II) with 2-amino-propane-1,3-diol of formula (III) without solvents and/or organic diluents to form an intermediate hexahydro-1,4-dioxa-6b-aza-cyclopenta(cd)pentalene of formula (IV); and (b) converting (IV) to (I) by heating the reaction mixture to a temperature of 100-200 degrees C for 1-500 minutes, or by adding a carbon allotrope or its derivatives.    R1-R6 = H, 1-30C alkyl, 2-30C alkenyl, 2-30C alkynyl, 2-30C linear or branched alkyl, aryl, alkyl-aryl, 2-30C linear or branched alkenyl-aryl, 2-30C alkynyl aryl or heterocyclyl.    An INDEPENDENT CLAIM is also included for the compound (IV) obtained by reacting (II) with (III) without solvents and/or diluents and/or acids.