NOVELTY - Method (M1) for self-sufficient enzymatic hydrolysis of lignocellulose-containing material, involves subjecting lignocellulose-containing material to pretreatment in pretreatment device, contacting the pretreated material with at least one enzyme belonging to class of hydrolase in a hydrolysis vessel to form a hydrolyzate, separating the hydrolyzate and subsequently dividing into two parts (i) and (ii), fermenting part (i) of the hydrolyzate with at least one microorganism or fungus capable of production of hydrolase enzyme, and redirecting the fermented hydrolyzate to vessel.    USE - The method (M1) is useful for self-sufficient enzymatic hydrolysis of lignocellulose-containing material. The (M2) is useful for producing organic compound chosen from organic acids, amino acids, caprolactams, antibiotics, vitamins, enzymes, nucleotides/nucleosides, biogas, proteins, polysaccharides, aminoglycans, organic solvents, biofuels, biosurfactants, and sugar derivatives (all claimed).    ADVANTAGE - The method enables to perform enzymatic hydrolysis in a cost-effective and environmentally-friendly manner without production of undesired substances.    DETAILED DESCRIPTION - Method (M1) for self-sufficient enzymatic hydrolysis of lignocellulose-containing material, involves (a) subjecting a lignocellulose-containing material to a pretreatment in a pretreatment device, (b) contacting the pretreated lignocellulose-containing material of step (a) with at least one enzyme belonging to class of hydrolase in a hydrolysis vessel to form a hydrolyzate, (c) separating the hydrolyzate and subsequently dividing the hydrolyzate into two parts (i) and (ii), where the part (i) is directed to a cultivation vessel, (d) fermenting part (i) of the hydrolyzate with at least one microorganism and/or fungus capable of production of at least one enzyme belonging to class of hydrolase, and (e) redirecting the fermented hydrolyzate of step (d) to the hydrolysis vessel of step (b), where the pretreated lignocellulose-containing material and/or hydrolyzate is treated to remove at least one substance inhibitory to at least one enzyme and/or at least one microorganism and/or fungus. An INDEPENDENT CLAIM is included for method (M2) for producing of an organic compound, which involves performing the above-mentioned steps (a)-(e), (f) contacting part (ii) of the hydrolyzate with at least one microorganism and/or fungus capable of the production of an organic compound chosen from organic acids, amino acids, caprolactams, antibiotics, vitamins, enzymes, nucleotides/nucleosides, biogas, proteins, polysaccharides, aminoglycans, organic solvents, biofuels, biosurfactants, or sugar derivatives and their mixtures, or subjecting part (ii) of the hydrolyzate to chemical conversion, catalytic conversion, chromatographic separation, membrane separation and/or crystallization process.