NOVELTY - Preparation of 2-(trans-4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone involves hydrogenating 2-(4'-chloro-1,2,3,6-tetrahydro-(1,1'-biphenyl)-4-yl)-1,4-dimethoxynaphthalene using noble metal catalyst at 25 degrees C, obtaining 2-(4-(4-chlorophenyl)cyclohexyl)-1,4-dimethoxynaphthalene in ethyl acetate, resultant compound with ceric ammonium nitrate in acetonitrile at 25 degrees C, oxidizing, obtaining 2-(4-(4-chlorophenyl)cyclohexyl)naphthalene-1,4-dione, epoxidizing resultant compound in presence of inorganic base and hydrolyzing using acid catalyst.    USE - Preparation of 2-(trans-4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone used as therapeutic agent for treating Pneumocystis carinii pneumonia, malaria, toxoplasmosis, carcinoma and fibrosarcoma.    ADVANTAGE - The method enables preparation of 2-(trans-4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone with high yield, by economical and environmentally-friendly process, without performing separation of diastereoisomers or geometric isomers.    DETAILED DESCRIPTION - Preparation of 2-(trans-4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone involves reacting 2-bromodimethoxy naphthalene and 4-(4-chlorophenyl)cyclohexanone, obtaining 4-(4-chlorophenyl)-1-(1,4-dimethoxy-naphthalen-2-yl)cyclohexanol in organic solvent, dehydrating resultant material in presence of bronsted acid at 60 degrees C, obtaining 2-(4'-chloro-1,2,3,6-tetrahydro-(1,1'-biphenyl)-4-yl)-1,4-dimethoxynaphthalene in toluene, hydrogenating resultant compound using noble metal catalyst at 25 degrees C, obtaining 2-(4-(4-chlorophenyl)cyclohexyl)-1,4-dimethoxynaphthalene in ethyl acetate, resultant compound with ceric ammonium nitrate in acetonitrile at 25 degrees C, oxidizing, obtaining 2-(4-(4-chlorophenyl)cyclohexyl)naphthalene-1,4-dione, epoxidizing resultant compound in presence of inorganic base and hydrolyzing using acid catalyst. INDEPENDENT CLAIMS are included for the following:    (1) 4-(4-chlorophenyl)-1-(1,4-dimethoxy-naphthalen-2-yl)cyclohexanol;    (2) 2-(4'-chloro-1,2,3,6-tetrahydro-(1,1'-biphenyl)-4-yl)-1,4-dimethoxynaphthalene; and    (3) 2-(4-(4-chlorophenyl)cyclohexyl)-1,4-dimethoxynaphthalene.